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An occasional problem achieving an erection is nothing to worry about. But failure to do so more than 50% of the time at any age may indicate a condition that needs treatment. Are you at risk for erectile dysfunction (ED)? Take the following quiz and find out.
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Depression affects the way one feels about oneself and the way one thinks about life. People who are depressed cannot simply "pull themselves together" and get better. Without treatment, symptoms of depression can last indefinitely. Appropriate treatment, however, can help most people who suffer from depression get back on track.
By increasing the intracellular concentrations of cyclic guanosine monophosphate (cGMP), phosphodiesterase-5 (PDE5) inhibitors such as sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) have been used therapeutically to treat erectile dysfunction (12), pulmonary hypertension (13), and cardiac hypertrophy (14). More recently, they were shown to induce apoptosis in different human tumors such as colon carcinoma and chronic lymphocyte leukemia (15, 16). In our mouse models, we show that pharmacologic PDE5 blockade down-regulates MDSC suppressive pathways and restores antitumor immunity. Moreover, our in vitro experiments using PBMCs from multiple myeloma (MM) and head and neck cancer patients suggest that the same mechanisms found in mice are also present in humans and demonstrate a possible role for PDE5 inhibitors as an immune adjuvant in the clinical setting.
The expression pattern of PDE11 has become the source of some controversy recently because of the drug tadalafil. Of the three major PDE5 inhibitors commonly used to treat erectile dysfunction (tadalafil, sildenafil, and vardenafil), only tadalafil has been found to have a relatively high affinity for PDE11 with a reported IC50 of ?73 nM (Tables 4 and 5) (Card et al., 2004; Weeks et al., 2005). Therefore, some scientists speculate that tadalafil will be more likely to have nonspecific side effects than sildenafil or vardenafil because of inhibitory effects on PDE11. Given that tadalafil inhibits PDE5 with substantially higher affinity (IC50 ?10 nM), our lack of information about physiological roles for PDE11, and the very similar safety profiles for all three drugs, it will probably take long-term trials to determine the validity of these speculations.
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If this is often happening to you then you ought to take the primary step and talk to someone. If you can admit the matter to yourself and your partner then you'll be able to get the assistance you need. As a rule, your partner already knows there's a drawback but isnít positive what they'll do about it. By talking it out you can research your options together. You arenít the only one who is laid low with this, and knowing that there are others in your position could help you to get the help that you just need.
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WEDNESDAY, Oct. 29 (HealthDay News) -- Cialis (tadalafil), a drug used to treat erectile dysfunction, appears effective in treating pulmonary hypertension, researchers report.
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Tadalafil has been shown to improve endothelial function in men with ED. Rosano et al studied brachial artery blood flow in 32 men with increased cardiovascular risk factors.6 They found that blood flow was significantly improved and this benefit remained for 2 weeks after cessation of the medication.
Sildenafil has been demonstrated to improve erectile function in diabetic patients, hypertensive patients, postĖtransurethral resection of the prostrate patients, radical prostatectomy patients following radiation therapy for prostate cancer, geriatric patients, spinal cord injury patients, and depression patients. As many as 66-90% of patients with ED secondary to brachytherapy or external beam radiation therapy for prostate cancer have significant improvements in erectile function.
There are no formal tests to diagnose erectile dysfunction. Some blood tests are generally done to exclude underlying disease, such as diabetes, hypogonadism and prolactinoma.
Erectile dysfunction was especially linked to diabetes. "It's important for physicians to know that more than 50 percent of their male diabetic patients are affected by erectile dysfunction," Selvin said.
Get regular exercise. Try to squeeze in at least 30 minutes of physical activity each day. Include aerobic and strength-training in your routine.
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The very fact that young males actually think they need this drug is all by itself alarming. But it's even more alarming to realize that Pfizer appears to be doing very little to restrict the sales of Viagra for recreational use.
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