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If One of These Drugs Isn't Effective for Erectile Dysfunction, Can I Try Another?
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Disclaimer: The authors of this article are responsible for its contents, including any clinical or treatment recommendations. No statement in this article should be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.
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Excessive stress is cause by the stressful life styles, no time for rest, putting yourself under the extreme conditions, too much of exercise, more exertion of body than body can face, and many other reasons. Excessive stress leads to the injure of entire health and makes you prone to many diseases. Stress activates the fight-or-flight response, where the adrenal glands release the hormones cortical and adrenaline into the blood stream. Cortical stimulate the liver to release sugar into the blood for quick energy. Adrenaline causes the blood vessels to constrict and increases breathing and heart rate, and shuts down the digestive system.
Physiology of Erection
The most common form of management in current practice is the use of one of the oral PDE-5 inhibitors. If one agent does not work adequately at its maximum dosage, another agent should be tried. Trying these medications 3-4 times is sometimes necessary before concluding that the therapy is ineffective. Men who have a vascular-leak (venous leak) phenomenon may need a constriction device placed at the base of the penis to maintain the erection, which may be effective by itself or in combination with a PDE-5 inhibitor. In selected cases, combination therapy with one of the PDE-5 inhibitors plus Yohimbine, MUSE, or intracavernosal injections can be tried. Although some men have taken two different PDE-5 inhibitors simultaneously, no evidence suggests any benefit and the risk of significant adverse effects is greatly enhanced. However, the use of both a shorter-acting agent and a longer-acting agent is not unreasonable at appropriate times and intervals as long as they are not taken together.
Erectile dysfunction isn't easy to talk about. Yet some 5% of 40-year-old men and up to 25% of 65-year-old men experience ED. WebMD's experts use plain, explicit language to give you information on erectile dysfunction causes, tests, treatments, and support. Here's where you and your partner can start building a better sex life.
It is this brain action that makes Uprima® a unique new approach to the treatment of ED. As Dr. Dula stated after being involved with a trial of 1472 patients using Uprima®; “From a urologist’s perspective, it is important to understand that this is an entirely novel agent and works totally different from Sildenafil (Viagra®). It is a centrally-acting agent. What’s more, apomorphine works fairly quickly, in 15-25 minutes. The main side effect is nausea, but over time and repeated dosages it rapidly dissipates. We think that it is a safe and efficacious treatment for erectile dysfunction.” (19)
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CONCLUSIONS: Sildenafil, vardenafil, and tadalafil are safe and effective PDE5 inhibitors for the treatment of ED.
Healthfacts, March, 1999 by Maryann Napoli
In the past, erection problems were thought to be "all in the man's mind." Men often were given unhelpful advice such as "don't worry" or "just relax and it will take care of itself." Today, doctors believe that when the problem is not temporary or does not go away on its own, physical factors are often the cause.
Hypogonadism (which leads to lower testosterone levels)
Thompson and his colleagues provided the first substantial evidence linking erectile dysfunction and subsequent risk for heart disease in a December 2005 report in the Journal of the American Medical Association. Yet the connection is not as well recognized among doctors and patients as cardiologists and urologists think it should be.
Erectile Dysfunction / Premature Ejaculation News
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Sildenafil is the first oral agent to be well documented as an effective form of treatment for men experiencing ED. Since its introduction in March, 1998, no other therapy for ED has achieved such prominent public recognition. Of the 250,000 American physicians who have written prescriptions for sildenafil, 14% have been written by urologists and 82% by nonurologists.
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Therefore, men with these conditions should not use tadalafil without having these conditions evaluated and stabilized first. For example, men with uncontrolled high blood pressure should have their blood pressure controlled; and men with potentially life-threatening abnormal heart rhythms should have these rhythms controlled.
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Neurologic Spinal cord injury; nerve injury (prostate surgery); stroke; peripheral neuropathy; incontinence; multiple sclerosis; Parkinson's disease Motor or sensory deficits; aphasia; gait abnormality; abnormal bulbocavernosus reflex; tremor
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According to the National Institute of Diabetes & Digestive & Kidney Diseases, it's estimated that about one-half of all people with diabetes have some kind of neuropathy. It becomes more common in those who are older, overweight, and those with high blood pressure.
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