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A useful and simple way to distinguish between physiological and psychological impotence is to determine whether the patient ever has an erection. If never, the problem is likely to be physiological; if sometimes (however rarely), it is more likely to be psychological.
Drugs like Cialis, Levitra and Viagra have revolutionized the treatment of impotence for millions of men over the past decade. However, some forms of erectile dysfunction remain very difficult to treat.
One way to know if the cause is physical or psychologic is to determine if you are having nighttime erections. Normally, men have 3 to 5 erections per night, each lasting up to 30 minutes. Your doctor can explain a test to find out if you are having the normal number of nighttime erections.
A new study sheds additional light on how erectile dysfunction (ED) interacts with diabetes. The study is another step in uncovering the link between the two disorders, and may lead to improved efficacy in treatments.
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Phosphodiesterase-5 (PDE5) inhibitors (sildenafil, tadalafil, and vardenafil) are agents currently in clinical use for nonmalignant conditions. We report the use of PDE5 inhibitors as modulators of the antitumor immune response. In several mouse tumor models, PDE5 inhibition reverses tumor-induced immunosuppressive mechanisms and enables a measurable antitumor immune response to be generated that substantially delays tumor progression. In particular, sildenafil, down-regulates arginase 1 and nitric oxide synthase–2 expression, thereby reducing the suppressive machinery of CD11b+/Gr-1+ myeloid-derived suppressor cells (MDSCs) recruited by growing tumors. By removing these tumor escape mechanisms, sildenafil enhances intratumoral T cell infiltration and activation, reduces tumor outgrowth, and improves the antitumor efficacy of adoptive T cell therapy. Sildenafil also restores in vitro T cell proliferation of peripheral blood mononuclear cells from multiple myeloma and head and neck cancer patients. In light of the recent data that enzymes mediating MDSC-dependent immunosuppression in mice are active also in humans, these findings demonstrate a potentially novel use of PDE5 inhibitors as adjuncts to tumor-specific immune therapy.
Sildenafil should be used cautiously in men on alpha blockers such as doxazosin (Cardura), terazosin (Hytrin), and tamsulosin (Flomax). There have been occasional reports of low blood pressure in men who have taken the two classes of drugs simultaneously and therefore it is recommended that there be at least a span of 4-6 hours between the ingestion of sildenafil and alpha blockers.
Nonpharmacologic options may be offered as second-line treatment in lieu of intraurethral or intracavernosal injection for patients who do not respond to or cannot tolerate oral therapy. Vacuum erection devices increase corporal blood flow, and a constrictor ring is then used to retain this blood within the penis. Satisfaction is variable (27%–74%), and this technique can cause discomfort and bruising of the penis.63 Surgical options exist for patients with erectile dysfunction. Penile arterial bypass surgery is appropriate in only a select group of patients (men under 35 years of age who have no generalized vascular disease and in whom an isolated injury has obstructed blood flow). Penile implants are available for patients who have not responded to more conservative treatment. This procedure is invasive, irreversible and subject to complications such as infection, erosion and mechanical failure. There is, however, a high rate of patient and partner satisfaction.63
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Premature ejaculation (when orgasm comes on too quickly) is not the same as impotence. Together with your partner, you should seek counseling for this problem, which is usually due to psychological factors.
Total testosterone levels: Blood samples for total testosterone levels should be obtained in the early morning (before 8 am) because of wide fluctuations in the testosterone levels throughout the day. A low total testosterone level suggests hypogonadism. Measurement of bio-available testosterone may be a better measurement than total testosterone, especially in obese men and men with liver disease, but measurement of bio-available testosterone is not widely available.
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Vasoactive drugs may also be injected intracavernosally. Such therapy represents an important second-line therapy for erectile dysfunction. It is the most effective pharmacologic treatment but has a high dropout rate because of the associated pain and apprehension involved. Phentolamine is an -blocker that was used in initial studies; its efficacy is poor, but it may be used in combination with other agents. Papaverine is a nonspecific PDE inhibitor and was the first effective intracavernosal therapy for erectile dysfunction. Currently, intracavernosal alprostadil therapy is preferred; it is more effective than other agents and produces fewer side effects. In a comparison study comparing alprostadil, a papaverine–phentolamine combination and papaverine alone, rates of success (ability to achieve and maintain an erection) of 72%, 61% and 31% were reported respectively.54 No patients in the alprostadil group experienced priapism, as compared with 2% and 4% of patients in the combination therapy and papaverine-only groups respectively. On the other hand, patients who used alprostadil were the only ones to report penile pain. For patients who do not respond to or do not tolerate alprostadil monotherapy, a triple mixture of papaverine, phentolamine and alprostadil may be prescribed. Such combination therapy has been shown to be more effective and, because of a lower dose of alprostadil, results in less pain.62 Complications of intracavernosal injections include pain, priapism and fibrotic changes at injection sites.
Tadalafil can cause hypotension (abnormally low blood pressure, which can lead to fainting and even shock) when given to patients who are taking nitrates. Patients taking nitrates daily, even patients taking nitrates only once a day, should not take tadalafil. Most commonly used nitrates are medications to relieve angina (chest pain due to insufficient blood supply to heart muscle because of narrowing of the coronary arteries). These include nitroglycerine tablets, patches, ointments, sprays, pastes, and isosorbide dinitrate and isosorbide mononitrate. Other nitrates such as amyl nitrate and butyl nitrate are found in some recreational drugs called "poppers".
Bob Dole is hawking Viagra. The ad, sponsored by the drugs manufacturer, Pfizer, seems to be everywhere in the print and broadcast media. Words like "courage" and "worthwhile" leap from the ad, as the former senator urges men to speak to their doctors about erectile dysfunction, the new term for impotence. In keeping with the current trend in prescription drug advertising, Viagra isnt mentioned in the ad. Instead, Pfizer is selling the illness of erectile dysfunction, or E.D., as it is referred to throughout the ad.
Learning to overcome ED is like learning any sexual skill; it takes patience, practice, and a partner. Solving erection problems is only a part of regaining a satisfying sex life. You and your partner have a whole world of erotic possibilities to explore. Remember the sexiest word in the language: communication.
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Sadeghi-Nejad noted that the study only addressed intercourse, and not masturbation. "This is essentially the same concept," Sadeghi-Nejad said. "Anything you can do to bring blood to the penis is beneficial," he added.
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Penile biothesiometry–This test uses electromagnetic vibration to evaluate sensitivity and nerve function in the glands and shaft of the penis. A decreased perception of vibration may indicate nerve damage in the pelvic area, which can lead to impotence.
Serfas, a manufacturer of biking accessories, set out to design a seat that would shift the rider's weight off the perineum. The result, called "the Eliminator," has a long groove down its middle and is hollowed out in front. In April 1999, researchers tested the newly designed seat on 15 regular cyclists, most of whom pedaled between 150 and 300 miles weekly.
In all seven trials, tadalafil was significantly better than placebo in improving men's ability to achieve and maintain erections. Improvements in erectile function was observed in some patients at 30 minutes after taking a dose; and improvements can last for up to 36 hours after taking Cialis when compared to placebo.
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The laboratory evaluation should be directed by the history and physical examination findings. The patient should be screened for any undiagnosed medical disease that may be the underlying cause of erectile dysfunction. A urinalysis, complete blood count and basic chemistry panel will help to rule out most metabolic and renal diseases.5,8 In elderly men, because thyroid disease can present subtly, the thyroid-stimulating hormone level should be measured to rule out thyroid dysfunction. In one study6 of men who underwent an endocrinologic evaluation for erectile dysfunction, 6 percent were found to have hypothyroidism, and their erectile function improved with treatment.
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